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As a non-ionic surfactant, nonoxynols are widely used in the detergent, textile, pesticide, coating, leather, building materials, paper, and other industries. They are known for their excellent emulsification, dispersant, and solubility properties. Nonoxynols are typically added to detergents to enhance their cleaning performance. They are also commonly found in fabric softeners, where they help to increase the softness of the fabric.

In the textile industry, nonoxynols are used in the production of synthetic and natural fibers. They help to improve the wettability and uniformity of the fibers during the dyeing process, resulting in brighter and more vibrant colors. Nonoxynols are also used as a wetting agent in the production of pesticides and herbicides, where they aid in the dispersion of the active ingredients, ensuring a more effective application.