N,N- dimethylformamide,is an organic compound, chemical formula C3H7NO, colorless transparent liquid. It is not only a kind of chemical raw material, but also a kind of excellent solvent with a wide range of uses. It can be mixed with water and most organic solvents freely, and has good dissolving ability for many organic and inorganic compounds.

Description:

Dimethylformamide for short DMF. A compound in which the hydroxyl group of formic acid is replaced by a dimethylamine group, HCON(CH3)2. It is a colorless transparent liquid with high boiling point, with a light amine flavor and a relative density of 0.9445(25℃). Melting point -61℃. The boiling point is 152.8℃. Flash point 57.78℃. Vapor density 2.51. Vapor pressure 0.49kpa(3.7mmHg25℃). Spontaneous ignition point 445℃. The explosive limit of vapor and air mixture is 2.2 ~ 15.2%. In case of open fire, high heat can cause combustion explosion. Can react violently with concentrated sulfuric acid, fuming nitric acid and even explode. It is soluble with water and most organic solvents. It is a common solvent for chemical reactions. Pure dimethylformamide is odorless, but industrial grade or spoiled dimethylformamide has a fishy smell because it contains an impurity of dimethylamine. The name comes from the fact that it is a dimethyl substitute for formamide (the amide of formic acid), and both methyl groups are located on the N (nitrogen) atom. Dimethylformamide is a polar (hydrophilic) aprotic solvent with high boiling point. Dimethylformamide is made using formic acid and dimethylamine. Dimethylformamide is unstable (especially at high temperatures) in the presence of a strong base such as sodium hydroxide or a strong acid such as hydrochloric or sulfuric acid and hydrolyzes to formic acid and dimethylamine. In the air and heating to boiling are very stable, when the temperature is higher than 350℃ that water loss, carbon monoxide and dimethylamine generation. N, N-dimethylformamide is a good aprotic polar solvent, can dissolve most organic matter and inorganic matter, with water, alcohol, ether, aldehydes, ketones, esters, halogenated hydrocarbons and aromatics are miscible. The positively charged end of the N, n-dimethylformamide molecule is surrounded by the methyl group, creating a spatial barrier that prevents the negative ions from approaching, but only the positive ions associate. The activity of the exposed negative ions is much greater than that of the solvated negative ions. Many ionic reactions are easier to perform in N, N-di metamimamide than in ordinary proton solvents. For example, carboxylic acids and hydrocarbons at room temperature React , Estes that can generate high yields, especially suitable for the synthesis of three -dimensional block blocking.

Applications Of DMF：

Dimethylformamide on a variety of polymers such as polyethylene, polyvinyl chloride, polyacrylonitrile, polyamide are good solvent, can be used for synthetic fibers such as polyacrylonitrile wet-spinning, polyurethane synthesis; Used for plastic film making; Can also be used to remove paint stripper; It can also dissolve certain low solubility pigments, giving them the characteristics of dyes. Dimethylformamide is used for aromatics extraction and for the separation and recovery of butadiene from C-4 and isoprene from C-5. It is also an effective reagent for the separation of non-hydrocarbon components from paraffin. It has good selectivity for the solubility of m-phthalic acid and terephthalic acid: the solubility of m-phthalic acid in dimethylformamide is greater than that of terephthalic acid, and the two can be separated by solvent extraction or partial crystallization in dimethylformamide. In the petrochemical industry, dimethylformamide can be used as a gas absorber to separate and refine gases. Chemicalbook is mainly used in wet synthetic leather production as washing and curing agent in polyurethane industry. As solvent in acrylic fiber industry, it is mainly used for dry spinning of acrylic fiber. In the electronic industry as tin plating parts quenching and circuit board cleaning; Other industries include carriers of dangerous gases, solvents for drug crystallization, adhesives, etc. In organic reactions, dimethylformamide is not only widely used as a solvent, but also as an important intermediate in organic synthesis. It can be used in the pesticide industry to produce chloramidine; In the pharmaceutical industry, it can be used for the synthesis of iodimidine, doxycycline, cortisone, vitamin B6, iodoside, protective pinnet, thiacil, n-formyllysarcomatine, antitumine, methoxyaryl, benazine, cyclohexanitrourea, fururacil, hemostatic acid, betamethasone, megestrel, biliviat, purmin, sulfanilamide drugs. Dimethylformamide has catalytic effect in hydrogenation, dehydrogenation, dehydration and dehalogenation reactions, which can reduce the reaction temperature and improve the purity of the product.

Universal solvent-dimethylformamide:

1.Dimethylformamide is primarily used as a low volatile solvent. Dimethylformamide is used in the manufacture of acrylic fibers and plastics. In the pharmaceutical industry, it is also used in the manufacture of insecticides, adjuvants, artificial leather, fibers, film and surface coating.

2.Dimethylformamide is a reagent for Bouveault’s aldehyde synthesis and for the Vilsmeier-Haack reaction, another useful aldehyde synthesis reaction. In NMR spectroscopy, the protons on the methyl group of dimethylformamide form two single peaks because the rotation rate of the carbonyl carbon-nitrogen bond is slow in NMR time scales. The carbonyl carbon-nitrogen bond has a bond order greater than one, while the amide carbon-oxygen bond has a bond order less than two. In the Chemicalbook infrared spectrum of an amide, the C=O band is usually less than 1700cm-1 because its C=O bond is weakened by the density of electrons from nitrogen to oxygen.

3.Dimethylformamide penetrates most plastics and causes them to expand, and is often used as one of the ingredients in paint removers.

4.Dimethylformamide is also known as a “universal solvent”, but it has its limitations. The boiling point is high, 154℃, as a solvent of many polymer materials is more appropriate, in organic synthesis to choose carefully, often encounter the solvent is not clean. In addition, it can be miscible with water, simple solvent recovery method is difficult to dehydrate, at the cost of time, can be washed off with water, in the small trial should consider the feasibility of large-scale production. We need to calculate the cost and the wastewater treatment plan.

Operation disposal and storage:

Operation precautions: closed operation, comprehensive ventilation. The operator must strictly abide by the operating procedures after special training. It is recommended that operators wear filter anti -virus masks (half masks), chemical safety protective glasses, chemical protective clothing, and rubber gloves. Stay away from fire and thermal sources, and smoking is strictly prohibited in the workplace. Use explosion-proof ventilation systems and equipment. Prevent the vapor leak into the air in the workplace. Avoid contact with oxidant, reducing agent, halogen, acid. Control should control the flow rate to prevent static accumulation. Due to lightly and lightly remove the packaging and container when moving. Equipped with the corresponding variety and quantity of fire equipment and leakage emergency treatment equipment. Empty containers may be harmful residues.

Storage precautions: stored in a cool, ventilated warehouse. Kuwen should not exceed 37 ° C, away from fire and thermal sources. Keep the container seal. It should be stored separately from the oxidant, reducing agent, halogen, etc., avoid mixing. Explosion -proof lighting and ventilation facilities. It is forbidden to use machinery and tools that are prone to sparks. The storage area should have leakage emergency treatment equipment and suitable containment materials.

Product packaging :190kg/drum,storage should be cool,dry,ventilated place.